Accurate determination of Azithromycin (AZM) in water

Overuse of the antibiotic azithromycin (AZM) has raised global concerns because it may cause antibiotic resistance and negative environmental impacts. AZM is often used to treat various bacterial infections, but these antibiotic residues can contaminate water sources and contribute to public health problems. Therefore, there is a need for an accurate and reliable method to detect and measure AZM concentrations in the environment.

Researchers have succeeded in developing an electrochemical-based sensor capable of measuring AZM concentrations with great accuracy, in response to concerns that excessive use of AZM is causing resistance and adverse environmental impacts. This sensor uses printed electrodes (SPCE) modified with boron doped diamond nanoparticles (BDDNP) and reduced-graphene oxide (rGO). Both materials are advanced nanomaterials that have excellent properties. Such a low backflow allows highly sensitive sensor results, as well as excellent chemical and physical resistance. Therefore, it is very helpful for sensor applications. With this approach, it is hoped that it can provide an effective solution in monitoring the presence of AZM in different environments. Especially in waters to reduce negative impacts and control the spread of antibiotic resistance.

Procedure

In this study, the morphology of the modified electrodes was investigated using scanning electron microscopy and energy-dispersive X-ray spectroscopy (SEM-EDX). Electrochemical parameters such as signal-to-background current ratio, scan rate, and selectivity are optimized to achieve optimal results. The results show that under optimal conditions, this sensor has a linear range of 30–100 μM with a limit of detection (LOD) of 1.6 μM. Recyclability and recovery tests were also performed, with the sensors applied to real samples obtained from hospital wastewater. The sensor recorded an excellent recovery rate of 93.27% and excellent precision with a %RSD of 2.41%. This study highlights the great potential of rGO/BDDNP-modified SPCE in accurately and reliably measuring AZM levels. Furthermore, it demonstrates its suitability in overcoming the challenges of AZM monitoring in different environments.

Author: Prastika Krisma Jiwanti, S.Sc., M.Sc.Eng., Ph.D.

Link: https://doi.org/10.1002/slct.202400520

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