“Well-liked despair medicine causes weight acquire”… Harvard College Examine｜Dong-A Ilbo

Some antidepressants have been proven to be related to weight acquire.

Researchers at Harvard Medical College and the Harvard Well being Care Institute (HPHCI) analyzed the burden of greater than 183,000 grownup antidepressant customers six months, one yr, and two years after beginning medicine.

In line with a paper revealed within the Annals of Inside Medication, Celexa (citalopram) and Lexapro (escitalop) are primarily based on Zoloft (sertraline), essentially the most prescribed antidepressant in the US as a consequence of a comparability with Prozac (Sertraline) knowledge. fluoxetine), Paxil (paroxetine), Wellbutrin (bupropion), Cymbalta (duloxetine), and Effexor (venlafaxine), the most important weight distinction was seen 6 months after taking the drug.

After half a yr of taking the drug, Lexapro, Paxil, and Cymbalta customers have been 10 to fifteen p.c extra more likely to acquire greater than 5 p.c of their beginning weight than Zoloft customers.

Whereas Prozac was not related to weight change after six months, Wellbutrin customers have been 15% extra more likely to expertise a 5% weight acquire. Wellbutrin confirmed the least weight acquire after 1 and a couple of years.

Researchers defined that Wellbutrin improves consciousness and a focus by growing dopamine and norepinephrine ranges within the mind. Used to deal with despair and seasonal affective dysfunction and to assist folks give up smoking, the drug has additionally been proven to stimulate the central melanocortin system, which regulates urge for food, vitality steadiness and physique weight.

In line with the New York Publish on the first (native time), the usage of antidepressants amongst adolescents and younger adults is growing in the US. In line with one examine, about 14% of American adults are taking antidepressants.

HPHCI researchers famous that folks typically cease utilizing medicines after they acquire weight. It’s hoped that this info, together with different components, will assist sufferers and medical doctors to decide on essentially the most applicable remedy.

Park Hae-sik, Donga.com reporter pistols@donga.com