Researchers from Europe and the US have developed a new vaccine technology that, in experiments on mice, appeared to provide protection against a wide “gamut” of coronaviruses that have the potential to cause future epidemics (or even pandemics) – including coronaviruses that they are still unknown to us as they have not emerged!
“Preventive Vaccination”
This new approach to vaccine development is called “preventive vaccinology” and involves making vaccines that can provide coverage against potentially dangerous pathogens that haven’t even appeared yet.
Targeting eight different coronaviruses
The new experimental vaccine works by training the immune system to recognize specific regions of eight different coronaviruses, including SARS-CoV-2 which was the ‘culprit’ of the recent coronavirus pandemic as well as some coronaviruses currently circulating in bats and appear to have the potential to jump to humans and cause a potential pandemic.
Protection also against unknown coronaviruses
“Key” to the effectiveness of this particular vaccine is that it targets areas of coronaviruses that are common to many of them. Thus, by training the immune system to attack these areas, the new vaccine effectively provides protection against coronaviruses that are not “represented” in it – including coronaviruses that have not yet been identified.
For example, the new vaccine does not include the SARS-CoV-1 coronavirus that caused the Severe Acute Respiratory Syndrome (SARS) epidemic in 2003, but induces an immune response against this virus as well.
Aim for a vaccine ready before a future corona pandemic
“Our goal is to develop a vaccine that will protect us from the next pandemic caused by the coronavirus and to have that vaccine ready before the next pandemic even starts,” said Rory Hills, a researcher at the Department of Pharmacology at the University of Cambridge and first author of the new related study which was published in the scientific journal “Nature Nanotechnology” and added: “We have created a vaccine that provides protection against many different coronaviruses, including coronaviruses that we do not know yet.”
For his part, the main author of the study, Professor Mark Howarth from the Department of Pharmacology at the University of Cambridge noted that “we do not need to wait for the emergence of new coronaviruses. We know enough about coronaviruses and the different immune responses to them that we can move forward with the development of preventive vaccines against currently unknown coronaviruses.”
“Building” vaccines in advance
Professor Howarth added that “scientists did a very good job producing a highly effective vaccine for COVID during the last pandemic, yet the planet faced a massive crisis with a huge number of deaths. We must strive to do better in the future, and a key ‘ingredient’ to achieve this success is to start ‘building’ vaccines in advance.”
Nanoparticles and “protein glue”
The new vaccine called by the “parents” of the “Quartet Nanocage” is based on nanoparticles. Chains of different antigens are attached to the nanoparticles using an innovative ‘protein glue’. Multiple antigens are included in the chains and train the recipient’s immune system to target specific regions common to many coronaviruses.
Broad immune response in mice
According to the new study, the experimental vaccine appeared to induce a broad immune response in mice, even in mice previously infected with the pandemic coronavirus SARS-CoV-2.
Simple design
The new vaccine is much simpler to design than other coronavirus vaccines currently in development, which its creators say will help speed its way to human clinical trials.
In fact, the technology developed by the researchers can be used to develop vaccines that will protect against many other pathogens.
Future clinical trials and challenges
It should be noted that this research is a “child” of the collaboration of researchers from the University of Cambridge, the University of Oxford and the California Institute of Technology (Caltech) and offers an improved proposal that “steps” on previous research work by Oxford scientists and of Caltech which concerns the development of an innovative “universal” vaccine for coronaviruses. Indeed, the vaccine developed by Oxford and Caltech is expected to enter phase 1 clinical trials in early 2025 – but its complex structure poses challenges for large-scale production.
The downside of conventional vaccines
Conventional vaccines contain a single antigen that trains the immune system to target a specific virus. Thus they cannot be sufficiently effective against many different existing coronaviruses or coronaviruses that have not yet emerged.
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I can easily defeat the coronavirus once and for all
For almost 20 years, I have done seven immunograms. I did the first immunogram in 2006, before I purposefully began to strengthen the immune system, t-cell counts are normal there, and in six immunograms made since 2017, t-cells have been increased in abs.number /mcl Because since 2014 I began to purposefully strengthen the immune system.If I do not have blood cancer, I have done more than 50 general tests, all indicators are normal except for lymphocytes, they are exceeded a lot. I did the tests for a period of 5 years. I did it in 33 clinics. I did an analysis for autoimmune diseases, I do not suffer from this disease
I have had 3 consultations with immunologists. The immunologist who gave me the first consultation looked at my 7th immunogram made on 04/17/2024 immediately after he made a second consultation, the conclusion was absolute lymphocytosis, although in the first consultation the conclusion was moderate absolutely relative lymphocytosis (according to the t-cell link) with relative neutropenia made on 10/04/2022. The paid immunologist who took place at the end of March copied the conclusion of the first immunologist. Absolute lymphocytosis with a lymphocyte value from 39 to 52 % in all blood tests where the number of lymphocytes is measured
I have been sick with coronavirus at least 5 times. I got sick for the first time in 2 days in August in severe form with symptoms: cough, sneezing, runny nose, fever and pain in muscles and head. When I got sick, when I recovered, and the fact that I was sick with coronavirus will be proved by the 33 polyclinic in Almetyevsk.On the second day, when the symptoms subsided, PCR was performed, whether he was sick or not, he was not sick on a more accurate device. The next day, a nurse came to see a coronavirus patient, first she communicated with me in a mask and then realized that I was not sick with coronavirus and continued her communication without a mask. The day after my recovery, my mother fell ill with the same symptoms but also with loss of sense of smell. And after a while, I underwent an in-depth medical examination 4 times, I was ill asymptomatically, an antibody test will prove. The last antibody test showed 316 BAU/ml, the analysis was done six months after re-vaccination, the last analysis of 240 BAU/ml was done 1.3 years after repeated re-vaccination.
I got over hepatitis B in a few days. Before I went to the hospital, the mental hospital was a day hospital. He was tested for AIDS hepatitis, the result was negative, after 3.5 months he went only to another hospital, the department of neurology. Repeated analysis was carried out, antibodies to hepatitis B were found, And after a month there were no antibodies left.It is written on the Internet that with t-cell immunity, antibodies disappear after 3 months.This means that I got hepatitis B while lying in a mental hospital, I did all 3 analyses in a reputable clinic where I do a similar analysis in all public hospitals of the city
As with such a strong immune system, I get sick so much. My t-cell immunity differs from innate immunity in that it lets in viruses and kills them without leaving the virus a single chance
My immunity can be used to make a medicine, a vaccine against coronavirus. How the medicine treats with 100% effectiveness in 1 day and how the vaccine protects for a long time. An analogue of my medicine was tested on US President Donald Trump
I suffer from three diseases: diabetes mellitus, diabetes insipidus, olivopontoceribral degeneration with cerebellar atrophy.the third disease leads to premature death and its treatment is very expensive