▲ Research has shown that certain reproductive indicators in women can have a negative impact on metabolic function, leading to type 2 diabetes and hypercholesterolemia. (Photo = DB)
[메디컬투데이=최재백 기자] Research has shown that certain reproductive indicators in women can adversely affect metabolic function, leading to type 2 diabetes and hypercholesterolemia.
A study published in ‘Cell Metabolism’ found that certain reproductive indicators in women, such as early puberty, excessive weight gain during pregnancy, and severe menopausal symptoms, can adversely affect metabolic function and lead to type 2 diabetes and hypercholesterolemia. .
Recently, researchers have found that gender-specific risk factors are important in assessing metabolic health, especially screening for reproductive risk factors in women, such as early menarche, polycystic ovarian syndrome (PCOS), excessive weight gain during pregnancy, and severe menopausal symptoms. It stated that evaluation is necessary for the prevention or treatment of metabolic diseases.
According to the research team, looking at reproductive factors related to metabolic health, early menarche before the age of 12 is associated with abnormal blood sugar, hypercholesterolemia, metabolic syndrome, and type 2 diabetes, and chronic irregular menstruation increases the risk of developing type 2 diabetes. This is big. PCOS is associated with obesity and type 2 diabetes, and gestational diabetes, excessive weight gain during pregnancy, and hyperlipidemia during pregnancy have adverse effects on maternal metabolic health later in life. On the other hand, the longer you breastfeed, the better your metabolic health and the lower your risk of type 2 diabetes and metabolic syndrome. Additionally, the more severe menopause symptoms are and the sooner menopause occurs, the greater the risk of developing type 2 diabetes, but it can be prevented through postmenopausal estrogen treatment.
The study did not look into how each reproductive indicator affects metabolic health, but most risk factors were expected to increase insulin resistance.
The research team largely divided risk factors into ‘genetics’, ‘hormonal fluctuations’, and ‘physiology (obesity)’. In particular, obesity (Adiposity) is a key factor as it is related to metabolic syndrome as well as other reproductive risk factors. They said there was a possibility that it was the underlying cause.
They explained that when reproductive risk factors promote obesity and increase insulin resistance, it leads to anovulation, which reduces globulin that binds to sex hormones and increases free testosterone.
Furthermore, they advised that unlike past medical history that cannot be changed through individual efforts, prognosis can be improved by controlling reproductive risk factors through active preventive measures.
The research team expects that lifestyle factors, including diet and exercise, and drug treatment will help improve the course of people at high risk of metabolic diseases due to a reproductive history. By adjusting the current diet, they can determine the impact of reproductive risk factors on metabolic health. They said they are researching whether it can be controlled.
Additionally, the researchers added, doctors should pay attention to gender-specific risk factors in addition to the typical risk factors they traditionally look for, such as smoking, diet, and exercise.
[ⓒ 메디컬투데이. 무단전재-재배포 금지]
2024-02-05 09:21:29
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