A team from the University of Iowa Carver School of Medicine recently published new research results in the journal Advanced Science, using cooking equipment to inspire the development of edible carbon monoxide foam to help treat cancer patients.
Autophagy refers to an evolutionarily conserved process in which the cell’s own structure uses the lysosomal mechanism to transport damaged organelles, misfolded proteins, and other macromolecules to the lysosome for degradation and reuse.
When the mechanism of regulating differentiation of human cells is disturbed, cancer is usually caused. Autophagy plays an important role in cancer, which can inhibit or increase the spread of cancer cells. In particular, it can increase the survival probability of cancer cells through autophagy. .
Therefore, autophagy has been a key direction in cancer target therapy research for many years, especially related drugs that improve the inhibitory effect of autophagy, such as chloroquine (Antimalarials Chloroquine) and Hydroxychloroquine (Hydroxychloroquine), etc., which are usually used to treat chemotherapy. Patients use it to enhance the anti-cancer effect.
However, clinical trial results show that the therapeutic effects of autophagy inhibitory drugs are quite polarized. They are effective for some cancer patients, while others have no effect at all. Therefore, there is still much to be learned in the medical community about the relationship between autophagy drugs and cancer treatment. A place to clarify.
When a team from the Carver College of Medicine at the University of Iowa in the United States studied past medical records, they found that there was a significant difference in the use of autophagy inhibitors to treat cancer between patients who smoked and those who did not smoke. The effect is more significant when patients use autophagy inhibitors.
The research team pointed out that autophagy has a greater reaction to gas transmitters in the nervous system, among which carbon monoxide is the most obvious. Carbon monoxide is the main gas produced after burning cigarettes. Therefore, the research team tried to design a method that can Patients can also ingest additional carbon monoxide from the outside without smoking.
Therefore, the team developed an edible foam that can trap specific gases, and designed a similar container using the foam spray can commonly used in pastry making. They injected a specific amount of carbon monoxide into the foam and allowed it to be taken by patients.
The team first used prostate and pancreatic cancer cells sampled from humans, and used three autophagy inhibitors: chloroquine, BAF-A1, and Lys05 respectively. After mixing with 250 ppm carbon monoxide, they observed that the autophagy inhibitory effect increased, and in the absence of Under the influence of the inhibitor, cancer cells and general human gastrointestinal cells will not reduce their viability due to carbon monoxide concentration.
The team then conducted mouse experiments. Mice that also had prostate and pancreatic cancer cells were divided into three groups. One group was treated with inhibitors and carbon monoxide foam, one group was treated with inhibitors only, and the third group was treated with no treatment as a control group. .
The experimental results found that the mouse group that used inhibitors and carbon monoxide foam at the same time had the highest degree of cancer cell elimination, and the treatment effect was obviously better than that of the group that only used inhibitors and the control group.
The team is very excited about the results of this experiment. After releasing the research results, it will continue to conduct clinical trials on humans in the future, hoping to bring new hope for targeted cancer treatment.
(Source of first picture:University of Iowa）
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2024-01-22 07:41:44
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