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Study Reveals Origins of Multiple Sclerosis and Genetic Risk Factors in Ancient Europeans

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15 Jan. 2024 10:01 a.m.

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recently An international research team led by experts Experts from the University of Cambridge in England, the University of Copenhagen in Denmark and the University of California, Berkeley in the United States obtained DNA sequences from 1,664 ancient people from various locations. throughout Western Europe and Asia By comparing these ancient genetic data or genomes with the DNA of modern people from the UK Biobank.

The team said the ages of the bones and teeth from which DNA was extracted range from the Middle Stone Age and Neolithic Age to the Bronze Age, Iron Age and Viking Age to the Middle Ages. But the oldest genome in the dataset comes from a person who lived 34,000 years ago, providing insight into the origins of multiple sclerosis (MS). MS) that results in visual abnormalities movement Sensation The team determined that Northern Europe has the highest prevalence of MS in the world. The new study finds that genes that increase the risk of MS were introduced into northwestern Europe around 5,000 years ago, coinciding with the start of the Bronze Age. The Yamnaya people, who raised sheep and cattle, migrated from the eastern region of southern Russia and present-day Ukraine. to Western Europe

At that time, the Yamnaya people had useful genetic characteristics. Prevent infection that may occur from raised sheep and cattle. But pathogenic infections increased in frequency during the Bronze Age because of close contact between people and domestic animals. as well as increased population density Nowadays, with widespread sanitation and medical care, These genetic variations exceed people’s immune needs. As a result, the risk of developing MS and other autoimmune diseases increases.

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#Unraveling #DNA #ancient #Europeans #years
2024-01-15 03:01:00

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