Lung cancer is one of the most common cancers in the world, and has ranked first in cancer mortality in Taiwan for many years. Now a team from Tulane University has discovered that a previously unknown molecular pathway may help prevent the spread of lung cancer.
The hero is an important protein called RBM10. Researchers pointed out that RBM10 can cooperate with two ribosomal proteins (RPL5 and RPL11) to directly target c-Myc for degradation and inhibit the growth of lung cancer by inhibiting c-Myc function. .
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RBM10 destabilizes c-Myc, a protein that drives cancer cell growth and proliferation when overexpressed, and blocks the spread of lung cancer, identifying for the first time an anti-cancer relationship between proteins.
To understand how RBM10 prevents the progression of lung cancer, we first imagine that there are 2 factories in a cell. Each factory is responsible for producing the parts that assemble a new protein machine. c-Myc plays an important role in this process. Without it, humans cannot survive. .
But sometimes the process of assembling new proteins goes wrong, and factories start producing incorrect parts. When cancer cells form, they will use c-Myc to continue producing the wrong parts to form tumors, and RBM10 acts like a censor, destabilizing c-Myc with the help of RPL5 and RPL11 and preventing tumor growth.
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More importantly, the team found that RBM10 mutations are common in lung cancer patients, so that they are unable to bind to RPL5 and RPL11 ribosomal proteins, lose their ability to inhibit c-Myc overexpression, and ultimately promote tumor growth.
The researchers hope to further study how RBM10 mutants work and look forward to developing anticancer drugs that inhibit the oncogenic activity of c-Myc in the future.
The new paper was published in the Proceedings of the National Academy of Sciences (PNAS).
(Source of first picture:pixabay）
2023-12-16 10:57:51
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