Research reveals why we itch Bacterial activity That people with normal skin still itch | Thaiger Thai news

Scientist doing an experiment What causes itching? Bacteria in the skin stimulate itching and send signals to the brain that require us to scratch. Even normal people who do not suffer from eczema suddenly feel itchy.

Liwen Deng, an expert at Harvard Medical School, started his research with the question: “Bacteria in the skin that make us itchy How can it act directly on our nerve cells?”

Dr. Deng used a group of rats to test bacteria. “Staphylococcus aureus” is a parasite that lives on the skin and mucous membranes of people and animals. Causes of abscesses and blisters to come into contact with the skin of a mouse It was found that they had more severe itching. Plus, the skin is more sensitive to the touch than before.

Staphylococcus aureus has been genetically engineered to identify the exact enzyme that causes itching. It turns out that the V8 enzyme is what triggers itching. By stimulating a protein called PAR1, found in skin nerve cells that send signals such as pain, heat and itching to the brain.

When the researchers repeated the experiment in a lab dish containing human neurons, They found that human cells responded to V8 as well.

Dr Deng said: “We show that these can be separated. Your skin doesn’t have to be inflamed to be trigger to itch. But the itchiness makes the inflammation on the skin more severe.”

This is because PAR1 is a protein involved in blood clotting. and is the main cause of itching. The researchers therefore determined a way to prevent itching by trying an approved anticoagulant. And it worked.

Lab rats with itching began to improve quickly when treated. Both in terms of itching and skin damage. Researchers believe that the drug can be used as an anti-itch treatment in humans. And it may be an ingredient in a new type of skincare.

From research on itching of Dr. Deng said “Itching can worsen the condition of patients with chronic skin diseases. These patients have microorganisms on their skin that we have proven can trigger itchiness.”

• Follow us at :
•