UMC Utrecht will lead an international consortium that is trying to understand why children who have had an RSV infection as a baby seem to have a higher risk of asthma later in life. The research is funded by a HORIZON HLTH 2023 grant of 7 million euros from the European Commission.
The RS virus has been associated with the development of asthma for many years. But it is not yet clear what changes in the immature lungs of genetically predisposed babies cause the later development of asthma. It is also not clear how damage to the immature lungs caused by RSV infection can be repaired.
In the CLARITY (Causative Link between respiratory syncytial viRus and chronic lung diseases: Identifying Targets for therapY) study, the researchers will use different methods to investigate which genetic risk factors and disease mechanisms lead to asthma caused by viruses.
Specifically, using 2 national cohorts, they will attempt to identify genetic risk factors and RSV strains that contribute to severe bronchiolitis. The researchers are also analyzing how RSV causes damage in the cell that causes asthma to develop. They use artificial intelligence to link the outcomes to current biological knowledge.
Bron:
2023-09-04 09:28:15
#Reducing #risk #asthma #RSV #infection #MedNet
