Expectation of the possibility of using biomarkers to predict the course of motor symptoms of Parkinson’s disease in the future
▲ (From left) Professors Chaejeong Park, Seokjong Jeong, and Seungho Cho (Photo Credit=Yongin Severance Hospital)
[메디컬투데이=이한희 기자] Yonsei University College of Medicine Yongin Severance Hospital, Department of Radiology, Professor Chae-Jeong Park, Professor Seok-Jong Jeong, Department of Neurology, and Professor Seung-Ho Jeong, Department of Neurology, Sanggye Paik Hospital, conducted a study on the fact that the larger the volume of the choroid plexus, which is involved in the production of cerebrospinal fluid, adversely affects the course of motor symptoms in Parkinson’s disease patients. recently announced.
Parkinson’s disease is a disease characterized by excessive accumulation of protein aggregates, Lewy Bodies, in the brain. Protein aggregate deposition is known to be promoted when there is a problem with the glymphatic system, which plays a key role in metabolite excretion in the brain.
Recently, as it has been revealed that there is a high correlation between the choroid plexus, which produces cerebrospinal fluid in the ventricles, and the glymphatic system, the role of the choroid plexus in the pathophysiology of degenerative brain diseases is drawing attention.
In Alzheimer’s disease, the choroid plexus has different morphological characteristics compared to the normal group, and it has been found that the volume of the choroid plexus increases with severe cognitive decline. It is not yet clear what it does.
It is known that various motor symptoms in patients with Parkinson’s disease are related to the gradual loss of dopaminergic neurons.
Accordingly, the research team performed dopamine transporter positron emission tomography (FP-CIT PET) and 322 patients diagnosed with Parkinson’s disease at Severance Hospital between April 2009 and September 2015 to confirm the relationship between choroid plexus volume and motor symptoms in Parkinson’s disease. Brain magnetic resonance imaging (MRI) was analyzed. In addition, during an average follow-up period of 5.4 years, the occurrence of dyskinesia, motor fluctuations, and gait freezing were confirmed, as well as Parkinson’s drug control records.
As a result of the study, the larger the choroid plexus volume, the more severe Parkinson’s motor symptoms and basal ganglia dopamine deficiency, the greater the likelihood of gait freezing, and the higher doses of Parkinson’s drugs used to control Parkinson’s motor symptoms. Through this, it was found that the larger the volume of the choroid plexus, the more adversely affected the course of motor symptoms.
Professor Jeong Seok-Jong said, “The volume of the choroid plexus can be confirmed through brain MRI performed early in the diagnosis of Parkinson’s disease, so it is relatively easy to predict the course of motor symptoms and drug requirements in patients with Parkinson’s disease.” We expect to be able to use the choroid plexus as a biomarker.”
Meanwhile, this study was published in the International Journal of Neurology, Neurosurgery and Psychiatry (IF 11.0).
Medical Today Reporter Lee Han-hee (hnhn0414@mdtoday.co.kr)
[ⓒ 메디컬투데이. 무단전재-재배포 금지]
2023-08-21 02:40:19
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