Saturday, August 19, 2023, 7:04 p.m.
Drugs targeting migraine (Targeted Therapy for Migraine)
Many people have probably heard of migraine headaches. Or may have had some headaches. But don’t really know what migraine headaches are? We came to find answers from Dr. Chayanuchit Chayangsu, MD, neurology physician. Center for Neurological Disorders Nawawet Hospital Described knowledge and understanding of migraine headaches.
Migraine headaches are actually headaches that are not directly caused by a brain disorder, such as a stroke. Brain hemorrhage or brain tumor It’s caused by an abnormality of a protein in the brain (CGRP), which is responsible for making headaches too sensitive to stimuli.
CGRP (Calcitonin Gene Related Peptide) is a type of protein present in everyone’s brain. Its function is to trigger headaches in comparison to other animal instincts. Since humans are out of instinct, we need a system to protect ourselves. When there is a stimulus, it will cause us to have a headache instead so that we can escape from that stimulus, in fact, we cannot always avoid the stimulus. Resulting in more and more headaches, eventually making the headache so severe that it cannot be controlled.
There are several types of headache triggers, including:
glare from sunlight Computer screen, iPhone, iPad, some smells such as cigarette smell, car smoke Strong perfume smell, including PM 2.5, some foods such as tea, coffee, cheese, chocolate, monosodium glutamate, inadequate sleep, insomnia, snoring, nighttime apnea, stress, hot weather. Women often have symptoms before menstruation or when the period is about to end.
These triggers can trigger headaches in just about anyone with the disease. are more sensitive to stimuli than others
headache treatment The correct thing is to take the medicine as soon as possible. From when the symptoms are mild, then gradually adjust the medication until the symptoms can be controlled. In addition, in some cases, medication is required to prevent frequent headaches. There are many types of drugs in this group, depending on the individual response. Both oral Botox or injections to prevent headaches. (Targeted Therapy for Migraine)
Currently, this medication is used to prevent migraine headaches. This is a CGRP antagonist that blocks the protein that triggers headaches. It’s injected under the skin. In order to control frequent headaches, this group of drugs is more effective than oral drugs. reduce the frequency ofheadacheCan be quite up to almost 60%, compared to about 30% of effective oral drugs (meaning of the word effective (Response rate), using the principle that can reduce the frequency of headaches by at least 50%), including side effects Side effects are rare and not serious.
Another issue that patients ask very often. “How do you know? that the headache It’s just a normal headache. or migraine headaches Or is it from something wrong with the brain?” really
I think the more important thing is Need to know what kind of headache with the risk of having something abnormal in the brain Rather than self-diagnosing migraine or not. At this point, I would like to see a doctor for a differential diagnosis.
These symptoms or indications As an aid to notice that the headache There may be a dangerous condition that requires immediate treatment.
1. Headache with fever
2. Having a history of cancer in any organ
3. There are abnormal symptoms of the brain as well, such as lethargy, incomprehensible talk blurred vision or abnormal vision, distorted face, distorted mouth, limb weakness or numbness especially hemisphere symptoms
4. Severe headache have severe vomiting especially severe pain like never before First time in people >50 years old (migraines often occur since adolescence)
5. Severe headache after head injury
6. Severe headaches in pregnant women
7. Have a congenital disease that is a disease that has low immunity or receiving immunosuppressive drugs
If you have any of these symptoms or conditions It is advisable to go to the hospital for differential diagnosis.
Finally, I would like to see the importance of visiting a doctor to treat headaches. More than taking the drug yourself. in order to be diagnosed with a dangerous or severe disease Including getting correct treatment and advice in treating migraine headaches.
If you have any questions, you can ask for details and ask for advice at Neurology Center, Navavej Hospital Tel. 02 483 9999 I Line: @navavej I www.navavej.com
2023-08-19 12:04:00
#Targeted #Therapy #Migraine
