Stem cells extracted from heart tissue discarded after surgery were injected into mice… Reduce intestinal inflammation and heal wounds
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It has been shown that stem cells extracted from tissues discarded from neonatal heart surgery can treat Crohn’s disease, a representative chronic inflammatory disease. [사진=게티이미지뱅크]A study has found that using mesenchymal stem cells extracted from discarded heart tissue during neonatal surgery can treat Crohn’s disease, a representative chronic inflammatory bowel disease.
A research team at ‘Chicago Ann & Robert H. Lurie Children’s Hospital’ in the United States announced that the treatment potential was proven by directly injecting newborn mesenchymal stem cells into mice suffering from Crohn’s disease (Crohn’s disease in which inflammation appears in the ileum). In Crohn’s disease, inflammation occurs in the ileum and appendix, the most common with 40-60%.
Dr. Arun Sharma (Regenerative Medicine and Surgery), first author of the study, said, “There have been clinical trials using mesenchymal stem cells derived from the heart of newborns to repair damaged hearts, but these robust cells have been used in inflammatory bowel disease models. This is the first time we have studied it,” he said. He is a professor of medicine at Northwestern University and his children’s hospital is a non-profit (corporate) organization.
The research team said, “The results of this study can be expected to lead to a promising new alternative therapy that avoids the three pitfalls of Crohn’s disease treatment: reduced therapeutic effect, serious side effects, and increased risk of gastrointestinal dysfunction.”
The research team has the task of developing a method of injecting stem cells into the body through the veins of the patient’s body. In this study, stem cells were only injected directly into the diseased part (lesion) of the small intestine that required surgical procedures.
“The goal is to use stem cells for prevention and treatment before the signs and symptoms of Crohn’s disease appear,” said Dr. Sharma. He added, “We may be able to apply this approach to other inflammatory diseases as well, and the potential is enormous.”
Crohn’s disease, an autoimmune disease, can occur anywhere in the digestive tract (mouth to anus). It occurs most often in the area where the large intestine and small intestine connect (the ileocaecal region). The symptoms of Crohn’s disease vary widely and differ from person to person. Symptoms such as diarrhea, abdominal pain, loss of appetite, weight loss, general weakness, and low-grade fever may occur.
Crohn’s disease causes arthritis, skin diseases (erythema nodosum, pyoderma gangrene), eye diseases (iritis, uveitis), kidney disease (kidney stones), and cholangitis. In particular, 30 to 50% of patients with Crohn’s disease in Korea suffer from anal diseases (hemorrhoids, fistulas).
The exact cause of Crohn’s disease is not known, but smoking is a strong risk factor. Patients who smoke are more likely to relapse and have worse symptoms after surgery. The results of this study (Multipotent Human Neonatal Cardiac-Derived Mesenchymal Stem Cells Modulate Ileitis In Vivo) were published in the journal Advanced Therapeutics.
2023-07-31 22:21:16
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