More than 40 percent of obese Americans have always dreamed of taking a pill instead of an injection, and this idea may soon become a reality.
The final results of two studies, published on Sunday night, revealed that high doses of the drug in Wigovy, taken as oral pills, may be just as effective as common injections.
A 16-month study of about 1,600 overweight or obese people who were already receiving treatment for type 2 diabetes concluded that high doses of the daily pill lowered blood sugar better than standard doses of Repelsys.
From an average adult weight of 96kg, the higher doses also resulted in a loss of between 6.8kg and 9.07kg, compared to around 4.5kg for the lower dose.
Another 16-month study of more than 660 obese or overweight adults with at least one obesity-related disease — but not diabetes — found that taking the 50-milligram pill daily helped people lose about 15 percent of their body weight. Their body weight is on average, or about 18.85 kilograms, compared to about 2,720 kilograms with a placebo.
The study authors said this was “remarkably consistent” with the weight loss resulting from weekly dosing of the highest dose of Wiggoi, but that the drug had side effects.
About 80 percent of participants who received any dose of semaglutide by mouth experienced symptoms such as mild to moderate gastrointestinal problems, such as nausea, constipation, and diarrhea.
In a trial of the 50-milligram obesity drug, there was evidence of higher rates of benign tumors in people who took the drug versus a placebo.
Moreover, about 13 percent of those who took the drug felt a “change in skin texture,” such as tingling or increased sensitivity.
2023-06-27 06:48:05
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