Is Immunization Infertility Preventable? ! Pre-pregnancy assessment, examination, treatment, and planned pregnancy will greatly increase the chances of successful pregnancy for immune mothers!
“The doctor said that I have immune problems, so it will cause repeated miscarriages. But I am obviously a healthy baby, all the health checks pass, and there are no symptoms before pregnancy. Why am I an “immune mother”?”
“The ANA antinuclear antibody index is too high!” Holding the freshly released blood test report, Lulu sighed and said, “After going around a lot, I have done test-tube babies five times, and the tears were almost drained before it was detected. It turns out I have an autoimmune antibody problem!”
Immune Moms, the New Fertility Problem of the 21st Century
According to statistics, autoimmune diseases are more likely to occur between the ages of 20 and 40, especially for women, which are about 8 times more likely than men. Therefore, the first to bear the brunt are women who are of childbearing age.
Dr. Weng Shaoping from Aiqun Chinese and Western Medicine Clinic, an authoritative domestic research on immune infertility, pointed out that there are often unexplained infertility, or recurrent or habitual abortion, or edema, thrombosis, high blood pressure, heart disease, and epilepsy may occur due to pregnancy. Pre-existing symptoms, premature birth, and even endangering the safety of the mother’s body, this group of mothers who have difficulties in conceiving and “take their lives to seek a child” are called “immune mothers”.
Many immune infertility patients, unless they have autoimmune diseases, such as thyroid abnormalities, lupus erythematosus, or xerosis, are diagnosed early, they do not have any disease symptoms at all, only when they encounter “pregnancy” , infertility, miscarriage, and infertility will occur. Therefore, many immune mothers have such questions: “Why me?”
What is “immune infertility”?
Overseas studies have pointed out that up to 40% of patients with long-term infertility or recurrent miscarriage with unknown causes are mostly caused by immune factors, which is “immune infertility”. Weng Shaoping, who led the team to treat nearly 10,000 immune infertility cases, pointed out that long-term follow-up observations have found that about 60% of patients with unexplained infertility have “autoimmune antibodies” in their serum in blood tests.
“Autoimmune” disease, as the name implies, means that when the immune system is normal, it should be compatible with its own tissue antigens and will not produce antibodies. Normal people only produce antibodies against the invasion of foreign bodies from the outside to eliminate the foreign invaders, thus protecting themselves.
But people with autoimmune diseases, due to the disorder of the immune system, the antibodies of the immune system have evolved from resisting foreign enemies to attacking their own cells, tissues and organs. The most obvious is the body’s inflammatory response, such as: redness, inflammation, pain, swelling wait. This autoantibody is the culprit of the occurrence of “autoimmune” diseases! For example: It will destroy the normal functions of the reproductive system, sperm motility, or attack the embryo, which will lead to infertility.
How does immune abortion happen?
Embryo found by autoimmune antibodies in the mother’s uterus▶ Antibodies to reject the embryo▶ Attack the embryo▶ Inflammation of the placenta
How do autoimmune diseases affect pregnancy?
Common autoimmune diseases include:
antiphospholipid syndrome
Among all immune diseases, it is the autoimmune disease most related to female pregnancy. It occurs more frequently in women aged 30-40, and it is also the most common invisible killer of pregnancy miscarriage.
lupus erythematosus
About half of women with lupus erythematosus have “antiphospholipid antibodies” in their blood, which can cause thrombosis and coagulation problems, easily interfere with placental function, and lead to miscarriage.
Thyroid disease
In pregnant women with hyperthyroidism, moderate to high symptoms may cause miscarriage, premature delivery, stillbirth, anemia, infection, pregnancy toxemia, placental separation, and postpartum hemorrhage. The most serious is that it may cause congestive heart failure to the mother, and the death rate is extremely high.
And hypothyroidism, more prone to abnormal ovulation, higher chance of infertility. In addition, hypothyroidism is difficult to detect, but it is easy to affect mothers and babies. Therefore, this has been listed as a routine test during pregnancy.
In addition, there are immune diseases such as rheumatoid arthritis and xerosis, which can also affect pregnancy.
Asymptomatic autoimmune diseases:
recurrent miscarriage
unable to conceive
If there are repeated miscarriages or inability to conceive smoothly, there may be a problem with the immune system. Some antibodies are too high, causing the body to treat the embryo as a “foreign object”. Therefore, it has been impossible to conceive smoothly.
Due to the disorder of the autoimmune system, there is a situation of “one’s own people fighting against one’s own people”. What is the reason that causes the autoimmune cells to “distinguish between ourselves and the enemy”?
“Age, environment, or genetic inheritance, or even diet may also affect it, but current medical technology has not been able to find out the exact reason.” Dr. Weng Shaoping, who has studied immune infertility for more than 20 years, pointed out: “But for sure, The problems caused by autoimmunity to pregnancy and childbirth are easy to form blood clots and block the blood vessels of the placenta, so that the embryo cannot be supplied with nutrients, causing the embryo to shrink. Or cause the placenta itself to become inflamed, produce antibodies and reject the embryo, resulting in miscarriage or Premature.”
Pay attention to the 7 warning signs of becoming an “immune mother”
It is generally believed that the problem of infertility is concentrated in older women, but immune infertility is regardless of age, and it is not a patent for older women.
Dr. Ma Peijun of Aiqun Chinese and Western Medicine suggests that if you have any of the following conditions, you should consider going to the rheumatology and immunology department for blood tests and immune-related examinations:
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Difficult to get pregnant for a long time
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Miscarriage or recurrent miscarriage before 9-10 weeks of pregnancy
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Have had two or three IVF sessions, all failed at the implantation stage.
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The husband and wife have normal examinations, but unexplained infertility
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Old age infertility
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Premature ovarian failure
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have constitutional allergies
What items should be checked for immune infertility?
Weng Shaoping’s analysis can be roughly divided into two categories with a total of 9 items:
The autoimmune antibody examination items related to immune diseases are as follows:
1. Antinuclear Ab (ANA)
The presence of ANA means that there are a variety of autoimmune antibodies against the nucleus in the body. For example: lupus erythematosus, rheumatoid arthritis, xerosis, scleroderma, dermatomyositis, mixed connective tissue disease, etc.
2. Immunoglobulin IgG
IgG accounts for 75% of the immunoglobulin in the blood, and antibodies deal with viruses, bacteria, and toxins. Many autoimmune antibodies are IgG. If the IgG index is too high, it means suffering from autoimmune diseases, such as: lupus erythematosus, rheumatoid arthritis, dryness syndrome, etc.
3. Related to lupus erythematosus and rheumatic autoantibodies as follows:
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Anti-phospholipid Ab (APA)
This antibody often appears in the serum of systemic lupus erythematosus (SLE), and often causes secondary antiphospholipid syndrome, which is prone to embolism, tumor, autoimmunity, lupus erythematosus, and fetal death in pregnant women.
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Anti-cardiolipin Ab(ACA)
Arterial embolism, tumors, thrombocytopenia, recurrent venous inflammation, lupus erythematosus, maternal fetal death.
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Anti-thyroid peroxidase antibody Anti-TPO Ab
Thyroid autoimmunity is the main cause of hypothyroidism or hyperthyroidism, and it is mostly related to genetics.
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Anti-thyroglobulin antibody Anti-thyroglobulin Ab
ATA is an autoantibody that often occurs in patients with autoimmune thyroid disease. Severity indicators of chronic thyroiditis and autoimmune antibody diseases.
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D-Dimer
To determine whether there is a blood clot problem, such as: acute arterial, coronary, pulmonary, deep vein thrombosis, or ovarian cancer, or rheumatoid arthritis.
4. Antisperm Antibodies
Decreasing the motility of sperm or hindering the motility of sperm will directly affect the fertilization of sperm eggs.
(Photo provided by: Aiqun Chinese and Western Medicine)
“Planned pregnancy” for immune infertility patients is very important!
If you have an autoimmune disease, will you be unable to conceive and have children for the rest of your life? Physician Weng Shaoping believes that as long as the “pre-pregnancy assessment” and “condition control” are done well, pregnancy and childbirth are not a problem. He recommends doing the following three assessments:
1. Is the current physical condition suitable for pregnancy?
Before pregnancy, first of all, it is necessary to control the condition. Only by reducing the immune index to the normal value can there be good eggs, good embryos, and a uterine environment suitable for embryo implantation. If the condition is not well controlled, implantation, miscarriage, premature delivery, or stillbirth may be difficult, which poses serious risks to pregnant women and fetuses. Therefore, before pregnancy, a doctor must evaluate whether the current situation is suitable for pregnancy.
2. Does the drug affect the fetus?
Before preparing for pregnancy, it is necessary to evaluate whether the drugs currently taken will affect the fetus.
3. Will the mother’s antibody affect the embryonic development?
It is necessary to check the autoimmune antibody index before pregnancy, closely observe the index changes, and evaluate whether it will affect the normal development of the embryo.
Weng Shaoping suggested that the treatment of immune infertility must be done through close consultation and cooperation between the reproductive department and the immunology department or IVF physicians who are fully familiar with the regulation of immune drugs. Diet adjustments are closely related to the pregnancy rate of immune infertility.
Once it is found that the concentration of autoimmune antibodies in the body is too high, it is necessary to take drug treatment before preparing for pregnancy, and wait for the immune status to stabilize before pregnancy can be carried out smoothly. Part of drug treatment includes: aspirin, steroids, immunosuppressants, heparin, or injection of immunoglobulin, lymphocyte immunotherapy, and “hyperbaric oxygen” can also be used for treatment. Regulating the immune system to the optimum state for pregnancy can help improve the quality of eggs and increase the success rate of embryo implantation.
“Beyond Immune Pregnancy Therapy Bible: From Problem Discovery to Detection, Preventive Treatment, and Immune Mothers’ Successful Pregnancy”
★Taiwan’s first guide book that provides complete professional answers to immune infertility problems
★7 major immune status tests that affect pregnancy ╳Guidelines for 8 preventive treatment methods
★ Not only worry about the needs of people who are affected by immune diseases, but also obstetricians and gynecologists are also looking for answers in this book
Author: Physician Weng Shaoping
CEO of Aiqun Chinese and Western Medicine Clinic
Lead and integrate physician teams in different fields,
Obtained the RTAC certification of the Australian Reproductive Medicine Association in 2018,
Became the first reproductive center certified by international authority in Taiwan.
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The original text is quoted from: Difficult to conceive, repeated miscarriages, may be immune infertility!Do a good job of 3-point evaluation before pregnancy to improve the success rate of treatment
2023-06-01 16:00:00
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