Hibernating brown bears prevent blood clots by keeping low levels of a key protein, which could lead to new medications for humans.

Bears are known for their incredible ability to hibernate for months at a time, without eating, drinking or moving. But what may come as a surprise is that their ability to survive long periods of inactivity may hold the key to preventing blood clots in humans. A recent study has found that hibernating bears have developed a unique way to keep their blood flowing properly, even during long periods of inactivity. Could this research lead to new treatments and therapies for one of the most common health concerns affecting millions of people worldwide? Let’s take a closer look at this fascinating topic.


Hibernating bears could hold the key to preventing blood clots in humans, according to new research published in the journal Science. Scientists found that during hibernation, bears maintain a low level of heat shock protein 47, or HSP47, which is normally found in connective tissues and in platelets where it helps blood clots form. When the researchers compared the blood samples of 13 brown bears taken when they were hibernating with those taken in the summer, they found that the winter samples had roughly one-fiftieth of the amount of HSP47 found in active bears. The researchers discovered mice who lacked HSP47 had fewer clots and lower inflammation levels than animals with the protein. Similarly, immobile pigs and people with spinal cord injuries also had low levels of HSP47, making them vulnerable to clotting. The potential for a medication that could replicate the bears’ winter-blood chemistry offers hope for people with long-term immobility issues, post-surgical patients and long-haul air passengers, lessening their risk of developing deep vein thrombosis.
 
Blood clotting occurs naturally when we are injured, with blood vessels releasing chemicals that activate proteins in plasma, causing platelets to form clots to stem bleeding. In cases such as deep vein thrombosis, however, the process activates inappropriately causing clots to form in blood vessels without an injury. DVT symptoms include swelling, pain, tenderness and redness of the skin in the lower leg, thigh, and pelvis, but in up to 50% of cases, there are no symptoms. Furthermore, the clots can block vital blood flow to the lungs, which can become life-threatening. Prolonged lack of activity, surgery and certain medications can all heighten the risk. HSP47 could become a potential target in medications to prevent DVTs, according to the report.


In conclusion, the concept of hibernating bears helping us beat blood clots may seem unusual at first. However, it is remarkable to see how nature can inspire medical breakthroughs. As researchers continue to study the unique physiological adaptations of hibernating bears, we may unlock further insights into human health. This is another reminder that we have much to learn from the world around us, and that sometimes the most unexpected discoveries can lead to life-changing treatments. As we continue to explore and innovate, let us never lose sight of the endless possibilities that can arise from looking beyond our own species.