◀ More ▶
Of course, it is an organ abnormality in the most severe cases
Rheumatoid arthritis with cognitive impairment
Meanwhile, the focus has only been on relieving inflammation.
There was.
Cognitive impairment and cognitive impairment
Simultaneous treatment paved the way.
Treatment includes dementia medications in clinical trials
It is getting more and more attention.
Journalist Cho Hyung-chan reports.
◀ Report ▶
Rheumatoid arthritis is genetic and environmental
In addition to immunity, we need to protect our body
Inflammation and inflammation when immune cells rush to the joints
It is an autoimmune disease that causes damage.
Scleritis, interstitial pneumonia and purpura
Accompanying, the inflammatory response also affects the brain,
It can cause depression and cognitive impairment
The cause was a labyrinth.
A Korean research team found that rheumatoid arthritis patients
They coexist in the joints and star cells of the brain
The Maobi enzyme is the common pathogenesis of both diseases
He was the first to discover that he was a human being.
Maobi inhibits signal transduction in nerve cells.
Activates a neurotransmitter called GABA.
If “KDS2010” is administered, which inhibits Maobi, joint inflammation and cognitive function are restored.
want.
Woojin Won / Researcher, Center for Cognitive Sociality, Institute for Basic Science
“Previous studies have shown that immune cells and
If the goal was to reduce inflammation
The mechanism of the goal has now been revealed. “
This was also confirmed by animal experiments.
KDS2010 is currently used for Alzheimer’s and other dementias.
It is receiving more attention as it is in clinical trials as a treatment
there is.
Simultaneous treatment of arthritis, cognitive impairment and dementia
Duration of development of a possible next generation rheumatoid treatment
It’s open.
Chang-Jun Lee / Director, Center for Cognitive and Social Studies, Institute of Basic Science
“In dementia, we found that the Maobi of reactive star cells
Because enzymes have been shown to be the cause
When this is suppressed by the same mechanism
Rheumatoid animals as animal models of dementia
Cognitive impairment was improved by inhibition in the model
It’s done.”
The results of this study were published in the world’s top 10 molecular medicine journal.
Official Journal of the Korean Society of Biochemical and Molecular Biology
It was published in ‘Experimental Molecular Medicine’.
This is MBC News Cho Hyung-chan.//
(Video coverage: Shin Shin-ho)
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