Reporter Huang Zhongqiu / Taipei Report
▲ Huang Limin said the “chosen person” may only have fewer receptors for the virus (photo / provided by National Taiwan University Hospital)
At present, about 1 in 3 people are diagnosed in China, but there are still people who have not yet been infected by the outbreak (20); Huang Limin, full-time chief of the pediatric department at National Taiwan University Children’s Hospital, said they have become “chosen people.” infected with other viruses, but these people are very few and the proportion is not high, and the general public cannot know if they are the natural choice. The best way to prevent infection is to get vaccinated. Huang Limin believes that the nasal spray vaccine, which is mainly for the protection of the upper respiratory tract mucosa, is the trend of the next generation of vaccines in the future.
Almost 3 years have passed since the global outbreak of the new corona epidemic, but there are still people who have never been infected by the epidemic. According to the media, many scientists around the world are trying to clarify the reasons for the “choice people. “.
The report found that the team of Mala Maini, a professor of viral immunology at University College London, conducted intensive monitoring of medical personnel exposed to high-risk environments who should have been infected but did not. A series of blood samples.
Although there are only 10 of these “chosen people” who have never been infected, as many as 6 people have cross-reactive T cells in their trachea. Furthermore, it has also been found internationally that “HLA-B * 15: 01” is a gene carried by infected but asymptomatic people.
Huang Limin, full-time chief of the Pediatric Department of National Taiwan University Children’s Hospital, said that in fact many people have “chosen the people” around them. These people will claim that everyone around them has been diagnosed and that they have not yet been infected, and they all claim to be “chosen people”. , but there is no factual basis.
Huang Limin said there could be two conditions for becoming a “chosen person”, one is that “he has fewer receptors for viruses”; the other is that he may have been infected with other viruses recently. These are actually similar relationships in the past. But this has little meaning for the general public, because the general public cannot know if he is the person of choice and relevant research is still lacking in China, so it is best to get vaccinated to prevent infection.
According to foreign reports, Mai Ni is working with a team from Oxford University to study a new vaccine, claiming that T lymphocytes in the tracheal mucosa can not only protect people from COVID-19, but also prevent COVID-19 so more effective than they are. vaccines currently on the market Viruses mutate and spread again.
Huang Limin said that in 2021 the team from the National Taiwan University Hospital also started developing a “nasal spray” vaccine. The difference from the injectable vaccine is that in the past the injectable vaccine could only produce IgG antibodies that formed protection against the lower airway, but remained in the upper airway anyway. There will be viruses; In addition to generating IgG antibodies, nasal spray vaccines can also generate IgA antibodies against the upper respiratory tract, which can strengthen airway resistance. In addition to avoiding serious diseases, it can also effectively prevent the spread of the virus.
The National Taiwan University team found from animal experiments that the effect of animal experiments on reducing the amount of virus in the upper respiratory tract is very significant, but Huang Limin revealed that due to the huge demand for clinical trials on the ‘man, at least nearly 200 million, the national vaccine research and development strategy is currently relatively “fluid”. It’s natural, “without many subsidies, and eventually, the related human trial plan originally scheduled for this year had to fail. Huang Limin believes that the development of more next-generation vaccines and needle-free nasal spray vaccines will be the trend. future.
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