The researchers were able to prevent the replication of coronavirus in human cells in the laboratory, using the Crispr genetic editing technique, according to a study published on Tuesday, which could pave the way for new treatments against COVID-19, informs AFP.
A team of Australian scientists has used an enzyme that binds to the virus’s RNA and degrades the area of the genome that it needs to replicate inside the cells, preventing it from multiplying and infecting other cells, reports Agerpres.ro.
Following these in vitro results, published in the scientific journal Nature Communications, researchers hope to begin animal studies soon.
The technology “molecular scissors“Crispr has revolutionized the manipulation of the genome with the precision and ease with which it can be used, compared to previous tools. It allows the DNA or RNA ribbon to be cut in a certain area and the genetic code inside the cell to be modified.
Its application has shown promising results in eliminating genetic mutations that lead to the development of cancers in children and clinical trials are underway to treat other cancers and rare genetic diseases, including sickle cell disease, beta thalassemia and a condition that causes blindness.
In a study published Tuesday, researchers adapted the tool to recognize Sars-CoV-2, the virus responsible for COVID-19, lead author Sharon Lewin of the Peter Doherty Institute for Infections and Immunity in Melbourne told AFP.
“Once the virus is recognized, the Crispr enzyme is activated and cuts the virus into piecesshe continued.
The technique has also been shown to be effective in stopping viral replication in virus samples belonging to the Alpha variant, which appeared in England in late 2020.
Several effective COVID-19 vaccines are already on the market, but few treatments are available and they are partially effective.
“We still need better treatment for people hospitalized because of COVID. The current possibilities (available drug treatments – na) are limited and, at best, reduce the risk of death by only 30%“Sharon Lewin pointed out.
But they will pass, “years, not months“Until the Crispr technique translates into large – scale treatments,” said the director of the Doherty Institute.
“Molecular scissors” technology could still be useful in the fight against COVID-19, she hopes, helping “one day“to development”an accessible and non-toxic oral antiviral drug“.
This research also paves the way for the treatment of other viral diseases, “including the flu, Ebola and possibly HIV,” said Mohamed Fareh of the Australian Oncology Research Institute’s Peter MacCallum Cancer Center, co-author of the study.
Scientists have used CRISPR gene-editing technology to successfully block the transmission of the SARS-CoV-2 virus in infected human cells, according to research released Tuesday that could pave the way for Covid-19 treatments. https://t.co/e3JJVFxbd3 via @RFI_En
— Saul of United (@Viatcheslavsos3) July 13, 2021
Scientists have used CRISPR gene-editing technology to successfully block the transmission of the SARS-CoV-2 virus in infected human cells, according to research released Tuesday that could pave the way for COVID-19 treatments. https://t.co/pkDle6axjV
— J. #EmergencyConfetti Doyle (@sibersong) July 13, 2021
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