TRIBUNPONTIANAK.CO.ID- Immune cells or immune cells will naturally fight infections caused by microbes, viruses and bacteria, as well as other ‘invaders’.
However, these immune or immune cells can also be reprogrammed or “trained” to respond more aggressively and vigorously to such threats.
That’s according to UCLA scientists who have discovered the fundamental rules that underlie this process in a particular class of cells.
In a study published June 18 in the journal Science, researchers identified key molecular mechanisms in macrophages, the infection-fighting cells of the innate immune system, that determine whether and how well those cells can be trained.
Their findings could help pave the way for future targeted strategies to improve immune system function.
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“Like a soldier or athlete, innate immune cells can be trained by past experience to become better at fighting infection,” said lead author Quen Cheng, assistant clinical professor of infectious disease at UCLA’s David Geffen School of Medicine.
However, he notes, previous researchers have observed that some experiences appear to be better than others for immune training.
“This surprising finding motivates us to better understand the rules that govern this process,” said Cheng.
According to the researchers, whether or not immune training occurs depends on how the cell’s DNA is wrapped.
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