SOME recent time AstraZeneca vaccine busy being discussed because it is said to contain trypsin (enzyme) from pigs. However, this is not true. This is as argued by a virologist and lecturer at the Bandung Institute of Technology School of Pharmacy, Dr. rer nat apt Aluicia Anita Artarini.
He revealed that the AstraZeneca Vaccine does not contain animal trypsin, but rather the enzyme trypsin which resembles a fungus.
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“AstraZeneca does not use animal trypsin in its production process and at the end. There is no trypsin,” he said in a virtual discussion ‘How is the Covid-19 Vaccine Manufacturing Process?’, Monday, March 29, 2021, as quoted from Among.
He said the AstraZeneca Vaccine uses the enzyme trypsin which comes from a fungus and is made specifically for the Covid-19 vaccine. This is stated in the documents of AstraZeneca and the Oxford Team which conducted clinical trials.
Trypsin is also not included in the vaccine formula, but is only used as a cutting tool for mammalian cells, which AstraZeneca purchased from a supplier of Bank Cells.
“It is an enzyme similar to trypsin activity and from fungi that is made by recombinants,” he explained.
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AstraZeneca and Oxford purchased HEK 923 Cells from a supplier named Thermo Fisher as one of the ingredients for making the vaccine.
The nature of the mammalian cell itself is attached to the container, so that it will be difficult for the growth process of the number of cells to be more numerous, and researchers need trypsin enzyme protein to cut so that cells do not stick to the container.
“Tripsin eventually dies together with his cell. So it’s like a double-edged knife, it is necessary to just cut it in the container, when it’s released, that’s it,” said Anita.
He explained that until now only HEK 923 cells could be used to multiply adenovirus.
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“Maybe if technology has developed, there are other cells that can be used. That’s one, and if a virus is from mammalian cells, it means you have to use mammalian cells, this is not just for the Covid virus but for any viruses,” he said.
“So can you change the ingredients? If the ingredients are replaced, the analysis will be different. The manufacturing process and the contents are changed, there is a safety risk, so there will be clinical trials. I think what is accepted in the country and the contents are the same,” he concluded.
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