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Radboud: ‘Obscure protein plays an important role in arteriosclerosis’

Published on 03/14/2021 7:06 AM | Nijmegen region

NIJMEGEN – Arteriosclerosis causes heart and cerebral strokes. Researchers at Radboudumc have discovered that the protein prosaposin plays an important role in arteriosclerosis. This was unknown until now.

Is possible prosaposine a new starting point for the treatment of atherosclerosis, they write in a publication Science Translational Medicine.

Chronic inflammatory response

Arteriosclerosis, also called atherosclerosis, is a disease of the blood vessels that causes heart and cerebral strokes. It arises because cholesterol accumulates in the vessel wall and causes a chronic inflammatory response there. Cholesterol lowerers can inhibit arteriosclerosis.

Heart and cerebral strokes

Recent research has shown that it can also prevent heart attacks and strokes. The challenge is to inhibit the inflammation of the vessel wall as specifically as possible, without impeding the rest of the body’s defenses that protect us against infections.

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