[표지로 읽는 과학] Clue to Solving Lysosomal Disease Found: Dong-A Science

The international academic journal Science published an unidentified pink mass as a cover on the 7th. In the middle is the phrase “Enzyme Trafficking”. Below it, the sentence “In the Golgi apparatus, LYSET ensures the targeting of the newly synthesized lysosomal enzyme”.

The Golgi apparatus is an organelle found in most eukaryotic cells. The intracellular location of the Golgi apparatus varies from organism to organism. In mammals, the Golgi apparatus is located near the nucleus, while in yeast it is scattered throughout the cytoplasm. The label depicts the Golgi apparatus carrying the newly synthesized lysosomal enzymes to the lysosome.

Lysosomes are intracellular organelles containing various hydrolytic enzymes in small lipid sacs. Lysosome dysfunction causes various diseases such as neuralgia and Fabry disease, a rare genetic disease. Some viruses, including the novel coronavirus infection virus (COVID-19), can paralyze lysosomes and cause symptoms.

Thomas Brolke, professor of osteology and biomechanics at Eppendorf University in Germany, and Jan Karret, professor at Stanford University in the United States, released a study this week in Science showing that restoration plays an important role in proper lysosomal function. They found that cells without restoration had problems with the production of lysosomal enzymes.

Johannes Zuber, professor at the Institute of Molecular Pathology at the University of Vienna in Austria, and Wilhelm Pam, a team of researchers responsible for cell signaling and metabolism at the German Cancer Research Center, published a study this week on Science showing that recovery plays an important role when uptake occurs. In the absence of recovery, the lysosomes are depleted of enzymes and lose their ability to digest extracellular proteins.

These two studies should serve as basic research to help treat lysosome-related diseases. “The two studies confirmed the role and properties of restoration in ensuring efficient transport and targeting of lysosomal enzymes,” said Science.