Supply time2024-07-02 05:00
US analysis crew “Swap is the KLF-15 protein…suggests new weight problems therapy could also be developed”
(Seoul = Yonhap Information) Reporter Jooyoung Lee = American researchers have discovered a method to change white fats cells, which trigger weight problems, to beige fats cells, which burn energy. These outcomes clarify the explanations for the failure of scientific trials of associated remedies and are anticipated to result in the event of latest weight reduction medicine.
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Professor Brian Feldman’s crew on the College of California, San Francisco (UCSF) reported within the medical journal Journal of Scientific Investigation on the 2nd, by means of experiments with mouse fashions and human adipocytes, that white fats adjustments to beige fats when a sure outcome can be produced. protein is restricted.
Mammals, together with people, have three varieties of fats cells: white, brown and beige. White fats shops energy, whereas brown fats burns power and helps keep physique temperature. Beige fats has the traits of white and brown fats and burns energy, however not like brown fats, which types lumps, it accumulates between white fat.
Mammals are born with brown fats, however most brown fats in people disappears within the first 12 months of life. Nonetheless, once they eat or in chilly environments, white fats adjustments to beige fats.
Scientists have tried to develop medicine to transform white fats to brown or beige fats to deal with weight problems, however they haven’t succeeded.
Professor Feldman stated that many individuals have tried to create brown fats from stem cells, and that this research was looking for a mutation that adjustments white fats cells into beige fats cells.
The analysis crew targeted on the protein ‘KLF-15’, which was discovered to have an vital position within the metabolism and performance of fats cells in earlier research.
After we studied how KLF-15 labored in mice that retain brown fats all through their lives, we discovered that KLF-15 was extra plentiful in white fats cells than in brown or beige fats cells.
Then, when mice with white fats cells missing KLF-15 had been created, the white fats within the physique was discovered to be transformed to beige fats.
The analysis crew additionally discovered by means of exams on human fats cells that KLF-15 regulates the quantity of a receptor referred to as ‘Adrb1’, which is concerned in sustaining power steadiness.
The analysis crew stated, “Scientists found that stimulation of the ‘Adrb3’ receptor in mice causes weight reduction, they usually carried out scientific trials of medicine that work on this, however the research failed that the targets of those medicine had been mistaken.
“Medicine that concentrate on the human Adrb1 receptor are prone to be efficient,” stated Professor Feldman, “They could have vital benefits over new weight reduction medicine that suppress urge for food and blood sugar .
He continued, “This methodology doesn’t have an effect on the mind and solely works on fats accumulation, avoiding unwanted effects. Though now we have not but reached the end line, it’s clear that this discovery might have a significant affect on the therapy of weight problems.” added.
◆ 출처 : Journal of Scientific Investigation, Brian Feldman et al., https://www.jci.org/
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2024/07/02 05:00 Posted
2024-07-01 20:00:02
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